ANCA-associated vasculitides

ANCA-associated vasculitides (AAV) are diseases caused by vasculitis in which antineutrophil cytoplasmic antibodies (ANCAs) can be detected in the blood.[1][2]

Types

Three main AAVs are Churg-Strauss syndrome, microscopic polyangiitis and Wegener's granulomatosis. All feature a small-vessel vasculitis.

Polyarteritis[3] and pauci-immune rapidly progressive glomerulonephritis also feature ANCA antibodies. Some cases of polyarteritis nodosa, especially presenting microscopic polyangiitis, will be p-ANCA positive.[4]

References

  1. ^ Mansi IA, Opran A, Rosner F (April 2002). "ANCA-associated small-vessel vasculitis". Am Fam Physician 65 (8): 1615–20. PMID 11989638. 
  2. ^ Ozaki S (June 2007). "ANCA-associated vasculitis: diagnostic and therapeutic strategy". Allergol Int 56 (2): 87–96. doi:10.2332/allergolint.R-07-141. PMID 17460438. http://ai.jsaweb.jp/fulltext/056020087/056020087_index.html. 
  3. ^ "ANCA antibodies". http://www.ii.bham.ac.uk/clinicalimmunology/CISimagelibrary/ANCA.htm. 
  4. ^ Seishima M, Oyama Z, Oda M (2004). "Skin eruptions associated with microscopic polyangiitis". Eur J Dermatol 14 (4): 255–8. PMID 15319159. http://www.john-libbey-eurotext.fr/medline.md?issn=1167-1122&vol=14&iss=4&page=255. 
General
Other hypersensitivity/autoimmune
Other

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)